The TREAT Longevity Diet

longevity diet

The TREAT Longevity DietTM is the Oregon Longevity Project’s synthesis of the traditional Mediterranean diet combined with time-restricted eating. The Mediterranean diet is well known for its longevity benefits. With the fine tuning provided in our TREAT Diet, along with intermittent fasting and time-restricted eating(TREat), we are confident the diet can extend lifespan in every […]

Body type and response to resistance training

Ever wonder if different body types respond differently to exercise training? In simplistic terms, humans come in 3 basic body types: Endomorphs (round types with higher body fat, less muscle), Mesomorphs (square body types typically with lots of muscle), and ectomorphs (skinny body types who have little muscle or fat).  And it turns out that […]

mTOR Inhibition and Parkinson’s Disease

Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l-DOPA–Induced Dyskinesia Emanuela Santini1, Myriam Heiman Paul Greengard, Emmanuel Valjent, and Gilberto Fisone. Science Signaling  21 Jul 2009: Vol. 2, Issue 80, pp. ra36 Abstract Parkinson’s disease (PD), a disorder caused by degeneration of the dopaminergic input to the basal ganglia, is commonly treated with L-DOPA. Use of this drug, however, is severely limited […]

The role of senescence in neurodegenerative diseases

Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice Cellular senescence is characterized by an irreversible cell cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP), which is a major contributor to aging and age-related diseases. Clearance of senescent cells has been shown to improve brain function in mouse models of neurodegenerative diseases. However, it […]

Regenerative Orthobiologic Medicine, Defined

The use of any substance derived from a living source to treat or prevent disease is often referred to as a “biologic treatment,” which is derived from the Greek Bios, which means life.  The term “orthobiologics” refers to regenerative biologic treatments are those that use cells, plasma and growth factors in the treatment of orthopaedic […]

What is Metabolomic testing?

What is Metabolomic testing?

Metabolomics are advanced laboratory tests that give us insight into your metabolic phenotype. The first pillar of Oregon Longevity Project is a deep look into your overall health. We will collect blood and tissue samples for advanced laboratory testing, much more detailed and insightful than what would be performed in any routine physical examination. In […]

Joint Preservation with Orthobiologic Therapies

Joint Preservation with Orthobiologic Therapies

Joint pain can involve every aspect of our lives – walking, climbing steps, playing sports, working – and even sleeping. And even though it worsens as we age, joint pain can affect anyone at any age. Joint preservation can offer an effective alternative to surgical joint replacement, especially at the earlier stages of joint deterioration. Often […]

Why I follow Time Restricted Eating

Why I follow Time Restricted Eating

We define Time Restricted Eating (TRE) as consuming all of our daily calories within a 7-8 hour period of time, and consuming no calories for 16+ hours daily. You can readily accomplish this by beginning your caloric intake at noon with a healthy lunch, and finishing consuming calories no later than 7-8 PM. Because my […]

Reversal of epigenetic aging and immunosenescent trends in humans

Immune senescence is a predictable consequence of aging, and is responsible for many of the diseases of aging, including an increase in mortality from common respiratory infection, and cancer. The Thymus Regeneration, Immunorestoration and Insulin Mitigation (TRIIM) trial tested 9 white men between 51 and 65 years of age. It was led by immunologist Gregory […]

Senolytics: The Zombie Cell Assassins

Senolytics: The Zombie Cell Assassins

Senolytics are drugs and other therapeutics that kill senescent zombie cells and activate autophagy, the natural mechanism whereby we clear senescent cells from our bodies. Autophagy (literally self-digesting) is an essential mechanism that is taking place every second of our lives. But as we age, we accumulate greater populations of senescent cells, and the natural […]